UTSW Tests 200,000 Chemicals on Lung Cancer Cells, Finds 170 Candidates for Development

UT Southwestern’s Simmons Cancer Center has completed a five-year project during which researchers tested more than 200,000 chemical compounds on lung cancer lines. The early results showed 170 potential candidates for development into drug therapies for what is the most common cause of cancer death, according to the National Cancer Institute.

Researchers were after chemicals that would kill cancer cells without harming normal lung cells. The research was unique in that it began with the compounds, UT Southwestern says.

“Almost all cancer research is gene-first, or target-first,” says Dr. Michael Roth, a professor of biochemistry and member of the Simmons Cancer Center, in a statement.

Future research will focus on continuing to uncover the mechanism of action and testing additional forms of cancer for the 170 chemicals.